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An exposure prolonged to levels raised in blood patient Phe PKU can cause serious neurological damage. Levitra professioanal The launching of Kuvan therapy does not eliminate the need for an attentive follow-up from blood Phe levels and dietetic management in progress. Certain patients receiving Kuvan can know an important fall of the levels of Phe blood. The patients must be followed closely to take care that the blood levels Phe do not fall too low. They are not all the patients with PKU to answer the treatment. The response to the treatment can be given only by one therapeutic test. Kuvan was not studied among patients reached of renal or hepatic insufficiency. The patients who have these conditions must be supervised attentively. It is advisable to be careful with the administration of Kuvan to the patients who receive lévodopa and of the drug which assign nitric oxide to mediation vasorelaxation or metabolism of the folic acid. The majority of the serious adverse effects announced to the course Kuvan the administration (independently of the relation to the treatment) were gastrite, of the spinal cord, a streptococcic infection cancer of the testicles, and the urinary infection. Light with moderate neutropenia was also noted. The majority of the frequent adverse effects were the diarrhoea, headaches, of the abdominal pains, the infections of the higher respiratory tracts, pharyngo-larynx pain, of vomiting and nauseas. In connection with the phénylcétonurie Phénylcétonurie, a genetic disease concerning approximately 50000 patients in the developed world, is caused by an enzymatic deficit phenylalanine hydroxylase. HAP is necessary for the metabolism of phenylalanine, an essential amino acid finds in the majority of food containing of proteins. If the enzymatic activity is not present in sufficient quantity, Phe accumulates on levels abnormally high in blood and becomes toxic for the brain, resulting in a variety from complications, of which backwardness severe and cerebral lesions, the psychosis, convulsions, tremors, and limited cognitive Capacités. Viagra super active + Following the efforts of tracking of the new-born baby implemented in the years 1960 and at the beginning of the years 1970, practically all the sick PKU of less than 40 years in the developed countries were diagnosed with the birth. Currently, the phénylcétonurie cannot be managed by a mode restricts Phe -, which is supplemented by nutritional products of replacement, following the example formulas and food especially manufactured, but the strict diet is difficult for the majority of the patients to adhere to measurement necessary to reach an adequate control Of blood Phe levels. To know some more about the phénylcétonurie, please visit www.PKU.com. For more information on Kuvan, please visit